Are there susceptibility factors for primary progressive aphasia?

Abstract

The determinants of selective vulnerability in neurodegenerative diseases remain elusive. The asymmetric loss of neurons in primary progressive aphasia offers a unique setting for addressing this question. Although no factor can yet account for the selective vulnerability of the left hemisphere language network to degenerative diseases, a few themes are emerging as potential targets of further investigation.

Keywords: ApoE; Dementia; Dyslexia; Learning disabilities; Risk factors; Vasectomy.