Allosteric controls of nuclear receptor function in the regulation of transcription

Isabelle Billas; Dino Moras

doi:10.1016/j.jmb.2013.03.017

Allosteric controls of nuclear receptor function in the regulation of transcription

J Mol Biol. 2013 Jul 10;425(13):2317-29. doi: 10.1016/j.jmb.2013.03.017. Epub 2013 Mar 15.

Authors

Isabelle Billas¹, Dino Moras

Affiliation

¹ Department of Integrated Structural Biology, Institute of Genetics and Molecular and Cellular Biology, Centre National de la Recherche Scientifique, UMR 7104, Institut National de la Santé et de la Recherche Médicale U964, Université de Strasbourg, Illkirch 67404, France.

PMID: 23499886
DOI: 10.1016/j.jmb.2013.03.017

Abstract

Nuclear receptors control a large number of physiological events through the regulation of gene transcription. Their activation function involves and is controlled by ligands and multiple cofactors (repressors, activators and bridging proteins). Further post-translational modifications resulting from the crosstalk between different signaling pathways provide additional regulations. The numerous players involved allow the sophisticated fine-tuning of transcriptional regulation. The present review describes how allosteric mechanisms are used in the control of the sequential and ordered binding of nuclear receptors and the various protein effectors to target DNA.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Allosteric Regulation*
Crystallography, X-Ray
Gene Expression Regulation*
Models, Biological
Models, Molecular
Molecular Dynamics Simulation
Protein Conformation
Receptors, Cytoplasmic and Nuclear / chemistry*
Receptors, Cytoplasmic and Nuclear / metabolism*
Signal Transduction
Transcription, Genetic*

Substances

Receptors, Cytoplasmic and Nuclear