A photoresponsive supramolecular G-quadruplex

Org Lett. 2013 May 17;15(10):2350-3. doi: 10.1021/ol400610x. Epub 2013 May 3.

Abstract

Photoirradiation of a hexadecameric supramolecular G-quadruplex leads to a diastereoselective [2 + 2] cyclodimerization of half of its constituent subunits, which in turn shifts the equilibrium toward the formation of a precise heteromeric octamer.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Circular Dichroism
  • Deoxyguanosine / analogs & derivatives*
  • Deoxyguanosine / chemical synthesis
  • Deoxyguanosine / chemistry*
  • Dimerization
  • G-Quadruplexes
  • Magnetic Resonance Spectroscopy
  • Molecular Structure
  • Photochemotherapy
  • Stereoisomerism

Substances

  • 8-chalconyl-2'-deoxyguanosine
  • Deoxyguanosine