Bacterial sRNAs: regulation in stress

Chee-Hock Hoe; Carsten A Raabe; Timofey S Rozhdestvensky; Thean-Hock Tang

doi:10.1016/j.ijmm.2013.04.002

Bacterial sRNAs: regulation in stress

Int J Med Microbiol. 2013 Jul;303(5):217-29. doi: 10.1016/j.ijmm.2013.04.002. Epub 2013 Apr 11.

Authors

Chee-Hock Hoe¹, Carsten A Raabe, Timofey S Rozhdestvensky, Thean-Hock Tang

Affiliation

¹ Advanced Medical and Dental Institute (AMDI), Universiti Sains Malaysia, Kepala Batas, 13200 Penang, Malaysia. hcheehock@amdi.usm.edu.my

PMID: 23660175
DOI: 10.1016/j.ijmm.2013.04.002

Abstract

Bacteria are often exposed to a hostile environment and have developed a plethora of cellular processes in order to survive. A burgeoning list of small non-coding RNAs (sRNAs) has been identified and reported to orchestrate crucial stress responses in bacteria. Among them, cis-encoded sRNA, trans-encoded sRNA, and 5'-untranslated regions (UTRs) of the protein coding sequence are influential in the bacterial response to environmental cues, such as fluctuation of temperature and pH as well as other stress conditions. This review summarizes the role of bacterial sRNAs in modulating selected stress conditions and highlights the alliance between stress response and clustered regularly interspaced short palindromic repeats (CRISPR) in bacterial defense.

Publication types

Research Support, Non-U.S. Gov't
Review

MeSH terms

Bacteria / genetics*
Gene Expression Regulation, Bacterial*
RNA, Bacterial / genetics
RNA, Bacterial / metabolism*
RNA, Small Untranslated / genetics
RNA, Small Untranslated / metabolism*
Stress, Physiological*

Substances

RNA, Bacterial
RNA, Small Untranslated