Abstract
We report that the metazoan Wnt protease and signaling inhibitor TIKI shares sequence homology with bacterial TraB/PrgY proteins, inhibitors of pheromone signaling essential for propagation of antibiotic resistance. Our analysis suggests that these proteins represent an ancient metalloprotease clan regulating cellular communications across biological kingdoms.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bacteria / enzymology*
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Bacterial Proteins / metabolism*
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Catalytic Domain
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Cell Communication
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Drug Resistance, Bacterial / genetics
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Metalloproteases / metabolism*
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Pheromones / antagonists & inhibitors
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Protein Folding*
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Protein Structure, Secondary
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Protein Structure, Tertiary
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Proteolysis
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Sequence Homology, Amino Acid
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Wnt Proteins / metabolism*
Substances
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Bacterial Proteins
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Pheromones
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Wnt Proteins
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traB protein, Bacteria
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Metalloproteases