Lunar laser ranging has provided many of the best tests of gravitation since the first Apollo astronauts landed on the Moon. The march to higher precision continues to this day, now entering the millimeter regime, and promising continued improvement in scientific results. This review introduces key aspects of the technique, details the motivations, observables, and results for a variety of science objectives, summarizes the current state of the art, highlights new developments in the field, describes the modeling challenges, and looks to the future of the enterprise.