ABT-199 selectively inhibits BCL2 but not BCL2L1 and efficiently induces apoptosis of chronic lymphocytic leukaemic cells but not platelets

Br J Haematol. 2013 Oct;163(1):139-42. doi: 10.1111/bjh.12457. Epub 2013 Jul 4.
No abstract available

Keywords: ABT-199; BCL-XL (BCL2L1); BCL2; apoptosis; chronic lymphocytic leukaemia.

Publication types

  • Letter

MeSH terms

  • Apoptosis / drug effects*
  • Blood Platelets / metabolism*
  • Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
  • Cell Line, Tumor
  • Humans
  • Leukemia, Lymphocytic, Chronic, B-Cell / metabolism*
  • Proto-Oncogene Proteins c-bcl-2 / antagonists & inhibitors*
  • Sulfonamides / pharmacology*
  • bcl-X Protein / metabolism

Substances

  • Bridged Bicyclo Compounds, Heterocyclic
  • Proto-Oncogene Proteins c-bcl-2
  • Sulfonamides
  • bcl-X Protein
  • venetoclax