Mild and general palladium-catalyzed synthesis of methyl aryl ethers enabled by the use of a palladacycle precatalyst

Chi Wai Cheung; Stephen L Buchwald

doi:10.1021/ol401796v

Mild and general palladium-catalyzed synthesis of methyl aryl ethers enabled by the use of a palladacycle precatalyst

Org Lett. 2013 Aug 2;15(15):3998-4001. doi: 10.1021/ol401796v. Epub 2013 Jul 24.

Authors

Chi Wai Cheung¹, Stephen L Buchwald

Affiliation

¹ Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, USA.

Abstract

A general method for the Pd-catalyzed coupling of methanol with (hetero)aryl halides is described. The reactions proceed under mild conditions with a wide range of aryl and heteroaryl halides to give methyl aryl ethers in high yield.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Catalysis
Halogens / chemistry*
Heterocyclic Compounds / chemical synthesis*
Heterocyclic Compounds / chemistry
Methyl Ethers / chemical synthesis*
Methyl Ethers / chemistry
Molecular Structure
Palladium

Substances

Halogens
Heterocyclic Compounds
Methyl Ethers
Palladium

Abstract

Publication types

MeSH terms

Substances

Grants and funding