Seroepidemiologies of human metapneumovirus and respiratory syncytial virus in young children, determined with a new recombinant fusion protein enzyme-linked immunosorbent assay

Clin Vaccine Immunol. 2013 Oct;20(10):1654-6. doi: 10.1128/CVI.00750-12. Epub 2013 Aug 14.

Abstract

We compared antibodies against human metapneumovirus (HMPV) and respiratory syncytial virus (RSV) in children. The antibody nadirs for both viruses were at 3 to 5 months, and the majority of children were seropositive for both by 2 years. There was no significant difference in the kinetics of maternal antibody decline or seroconversion relative to the two viruses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Age Factors
  • Antibodies, Viral / blood*
  • Antigens, Viral* / genetics
  • Child
  • Child, Preschool
  • Enzyme-Linked Immunosorbent Assay / methods
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Male
  • Metapneumovirus / immunology*
  • Paramyxoviridae Infections / epidemiology*
  • Paramyxoviridae Infections / immunology
  • Recombinant Fusion Proteins / genetics
  • Respiratory Syncytial Virus Infections / epidemiology*
  • Respiratory Syncytial Virus Infections / immunology
  • Respiratory Syncytial Virus, Human / immunology*
  • Seroepidemiologic Studies

Substances

  • Antibodies, Viral
  • Antigens, Viral
  • Recombinant Fusion Proteins