Hemophagocytic lymphohistiocytosis: advances in pathophysiology, diagnosis, and treatment

J Pediatr. 2013 Nov;163(5):1253-9. doi: 10.1016/j.jpeds.2013.06.053. Epub 2013 Aug 15.
No abstract available

Keywords: ATG; Antithymocyte globulin; CTL; Cytotoxic T lymphocyte; EBV; Epstein-Barr virus; FHLH; Familial hemophagocytic lymphohistiocytosis; HCT; HLH; Hematopoietic stem cell transplantation; Hemophagocytic lymphohistiocytosis; IFN; IL; Interferon; Interleukin; MAC; MAS; Macrophage activation syndrome; Myeloablative conditioning; NK; Natural killer; RIC; Reduced-intensity conditioning; X-linked inhibitor of apoptosis; X-linked lymphoproliferative disease; XIAP; XLP.

Publication types

  • Review

MeSH terms

  • Diagnosis, Differential
  • Humans
  • Immunologic Deficiency Syndromes / diagnosis
  • Inflammation
  • Lymphocyte Activation
  • Lymphohistiocytosis, Hemophagocytic / diagnosis*
  • Lymphohistiocytosis, Hemophagocytic / genetics
  • Lymphohistiocytosis, Hemophagocytic / physiopathology
  • Lymphohistiocytosis, Hemophagocytic / therapy*
  • T-Lymphocytes, Cytotoxic / cytology