Abstract
Plasma isoniazid and rifampin concentrations, but not pyrazinamide and ethambutol concentrations, were decreased by about 50% (P < 0.05) in diabetic pulmonary tuberculosis patients. The prevalences of subnormal plasma isoniazid, rifampin, pyrazinamide, and ethambutol concentrations were 49% or 100% (P < 0.01), 66% or 100% (P < 0.05), 30% or 50% (P = 0.198), and 32% or 21% (P = 0.742) in nondiabetic or diabetic tuberculosis patients, respectively. These data show that plasma concentrations of isoniazid and rifampin were greatly reduced in diabetic tuberculosis patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Antitubercular Agents / blood
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Antitubercular Agents / pharmacokinetics*
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Antitubercular Agents / therapeutic use
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Biological Availability
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Diabetes Mellitus, Type 2 / blood
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / drug therapy*
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Diabetes Mellitus, Type 2 / microbiology
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Drug Administration Schedule
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Drug Dosage Calculations
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Ethambutol / blood
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Ethambutol / pharmacokinetics*
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Ethambutol / therapeutic use
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Female
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Humans
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Isoniazid / blood
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Isoniazid / pharmacokinetics*
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Isoniazid / therapeutic use
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Male
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Middle Aged
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Pyrazinamide / blood
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Pyrazinamide / pharmacokinetics*
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Pyrazinamide / therapeutic use
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Rifampin / blood
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Rifampin / pharmacokinetics*
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Rifampin / therapeutic use
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Tuberculosis, Pulmonary / blood
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Tuberculosis, Pulmonary / complications
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Tuberculosis, Pulmonary / drug therapy*
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Tuberculosis, Pulmonary / microbiology
Substances
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Antitubercular Agents
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Pyrazinamide
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Ethambutol
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Isoniazid
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Rifampin