Sphingomyelin and ceramide are physiological ligands for human LMIR3/CD300f, inhibiting FcεRI-mediated mast cell activation

J Allergy Clin Immunol. 2014 Jan;133(1):270-3.e1-7. doi: 10.1016/j.jaci.2013.08.008. Epub 2013 Sep 12.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Cell Degranulation
  • Cell Line
  • Ceramides / pharmacology*
  • Feedback, Physiological
  • Humans
  • Ligands
  • Mast Cells / immunology*
  • Mice
  • Mice, Mutant Strains
  • Passive Cutaneous Anaphylaxis / drug effects*
  • Passive Cutaneous Anaphylaxis / immunology
  • Protein Engineering
  • Receptors, IgE / metabolism
  • Receptors, Immunologic / agonists*
  • Receptors, Immunologic / genetics
  • Receptors, Immunologic / metabolism
  • Sphingomyelins / pharmacology*
  • Transgenes / genetics

Substances

  • CD300LF protein, human
  • Ceramides
  • FCER1A protein, human
  • Ligands
  • Receptors, IgE
  • Receptors, Immunologic
  • Sphingomyelins