TERRA -a calling card for telomerase

Mol Cell. 2013 Sep 26;51(6):703-4. doi: 10.1016/j.molcel.2013.09.011.

Abstract

Transcription of telomeric DNA has long been thought to inhibit telomerase. Using live cell imaging, in this issue, Cusanelli et al. (2013) now reveal a different scenario: telomeric RNA is preferentially generated at short telomeres and delivers telomerase to the chromosome end from which the transcript originated.

Publication types

  • Comment

MeSH terms

  • RNA, Untranslated / genetics*
  • Saccharomyces cerevisiae / genetics*
  • Telomerase / genetics*
  • Telomere Shortening / genetics*

Substances

  • RNA, Untranslated
  • Telomerase