Abstract
The E apoprotein plays a central role in lipoprotein metabolism. It is a key protein determinant responsible for the recognition of lipoproteins by specific lipoprotein receptors. Structure-function studies are providing insights into the normal function of this apoprotein in cholesterol homeostasis and into the clinical abnormalities resulting from the occurrence of specific mutants.
MeSH terms
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Antibodies, Monoclonal
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Apolipoproteins E / classification
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Apolipoproteins E / immunology
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Apolipoproteins E / metabolism*
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Binding Sites
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Binding, Competitive
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Epitopes
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Humans
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Hyperlipoproteinemia Type III / metabolism*
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Isoelectric Point
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Peptide Fragments / metabolism
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Receptors, Cell Surface / metabolism*
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Receptors, LDL / metabolism
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Receptors, Lipoprotein*
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Structure-Activity Relationship
Substances
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Antibodies, Monoclonal
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Apolipoproteins E
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Epitopes
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Peptide Fragments
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Receptors, Cell Surface
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Receptors, LDL
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Receptors, Lipoprotein
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apolipoprotein B,E receptor