Polyglutamation of methotrexate. Is methotrexate a prodrug?

J Clin Invest. 1985 Sep;76(3):907-12. doi: 10.1172/JCI112088.
No abstract available

Publication types

  • Review

MeSH terms

  • Animals
  • Bone Marrow / drug effects
  • Cell Line
  • Cell Transformation, Neoplastic / drug effects
  • Cell Transformation, Neoplastic / metabolism
  • Delayed-Action Preparations
  • Humans
  • Intestinal Mucosa / drug effects
  • Kinetics
  • Methotrexate / analogs & derivatives
  • Methotrexate / metabolism*
  • Methotrexate / pharmacology
  • Methotrexate / toxicity
  • Peptide Synthases / metabolism
  • Peptides / metabolism*
  • Polyglutamic Acid / analogs & derivatives
  • Polyglutamic Acid / metabolism*
  • Tetrahydrofolate Dehydrogenase / metabolism
  • Thymidylate Synthase / antagonists & inhibitors

Substances

  • Delayed-Action Preparations
  • Peptides
  • Polyglutamic Acid
  • methotrexate polyglutamate
  • Tetrahydrofolate Dehydrogenase
  • Thymidylate Synthase
  • Peptide Synthases
  • folylpolyglutamate synthetase
  • Methotrexate