Abstract
A group of calcium-binding proteins which bind to biomembranes has recently been identified in widely different cells and tissues (refs 1-7, reviewed in ref. 8). Three of these proteins (p70, p36 and p32.5) cross-react with antiserum to calelectrin, a Ca2+-binding protein (relative molecular mass 34,000 (34K] from the ray Torpedo marmorata, giving rise to their designation as calelectrin-related proteins. We now report that calelectrin, p36 and p32.5 contain a 17-amino-acid consensus sequence which is conserved and present in multiple copies. We suggest that this sequence may be common to other members of this new group of Ca2+-binding proteins and may underlie their unusual mode of combination with biomembranes.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Animals
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Annexin A5
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Annexins
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Antibodies, Monoclonal / immunology
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Calcium-Binding Proteins / metabolism*
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Calmodulin-Binding Proteins / metabolism
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Endoplasmic Reticulum / metabolism
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Epitopes
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Intracellular Membranes / metabolism*
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Oncogene Protein pp60(v-src)
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Peptide Fragments / analysis
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Proto-Oncogene Proteins / metabolism
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Proto-Oncogene Proteins pp60(c-src)
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Retroviridae Proteins / metabolism
Substances
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Annexin A5
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Annexins
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Antibodies, Monoclonal
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Calcium-Binding Proteins
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Calmodulin-Binding Proteins
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Epitopes
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Peptide Fragments
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Proto-Oncogene Proteins
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Retroviridae Proteins
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Oncogene Protein pp60(v-src)
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Proto-Oncogene Proteins pp60(c-src)