Abstract
The experimental preclinical study on mice showed that a complex of polyhydroxylated naphthoquinone pigments and minerals from shells of sea urchins decreases the concentration of glucose, stimulates the synthesis of phospholipids in liver, and has antioxidant properties. On the model of streptozotocin-nicotinamide-induced type II diabetes, this complex of polyhydroxylated naphthoquinone pigments and minerals from sea urchin shells exhibited activity after administration for 10 days in a dose of 1.8 mg/kg.
MeSH terms
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Animal Structures / chemistry
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Animals
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Blood Glucose / metabolism*
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Diabetes Mellitus, Experimental* / blood
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Diabetes Mellitus, Experimental* / drug therapy
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Diabetes Mellitus, Type 2* / blood
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Diabetes Mellitus, Type 2* / drug therapy
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Hypoglycemic Agents / chemistry
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Hypoglycemic Agents / pharmacology*
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Male
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Mice
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Oxidative Stress / drug effects*
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Pigments, Biological / chemistry
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Pigments, Biological / pharmacology*
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Sea Urchins / chemistry*
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Time Factors
Substances
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Blood Glucose
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Hypoglycemic Agents
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Pigments, Biological