Abstract
Two large-scale pharmacogenomic studies were published recently in this journal. Genomic data are well correlated between studies; however, the measured drug response data are highly discordant. Although the source of inconsistencies remains uncertain, it has potential implications for using these outcome measures to assess gene-drug associations or select potential anticancer drugs on the basis of their reported results.
Publication types
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Comparative Study
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Research Support, N.I.H., Extramural
MeSH terms
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Antineoplastic Agents / pharmacology*
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Area Under Curve
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Cell Line
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Drug Resistance, Neoplasm / drug effects
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Drug Resistance, Neoplasm / genetics
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Gene Expression Profiling
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Genome, Human / genetics
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Humans
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Inhibitory Concentration 50
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Neoplasms / drug therapy
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Neoplasms / genetics
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Neoplasms / pathology
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Pharmacogenetics*
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Reproducibility of Results