Acute stress enhances the activity of the GABA receptor-gated chloride ion channel in brain

Brain Res. 1987 May 12;411(1):151-5. doi: 10.1016/0006-8993(87)90692-5.

Abstract

The effect of acute swim stress on the functional activity of the gamma-aminobutyric acid (GABA) receptor/chloride ion channel was studied using an assay to measure 36chloride (36Cl-) uptake into rat brain synaptoneurosomes. Muscimol-stimulated 36Cl- uptake in cerebral cortex, hippocampus, but not cerebellum, was enhanced (increased potency and efficacy) in rats subjected to 10 min of swimming, compared to non-stressed, control rats. The effect of swim stress on the activity of the GABA receptor/Cl ion channel was prevented by adrenalectomy.

MeSH terms

  • Adrenalectomy
  • Animals
  • Brain / drug effects
  • Brain / metabolism*
  • Brain / physiopathology
  • Chlorides / metabolism*
  • In Vitro Techniques
  • Ion Channels / drug effects
  • Ion Channels / metabolism*
  • Male
  • Muscimol / pharmacology
  • Rats
  • Rats, Inbred Strains
  • Receptors, GABA-A / drug effects
  • Receptors, GABA-A / metabolism*
  • Stress, Physiological / metabolism*
  • Swimming
  • Synaptosomes / drug effects
  • Synaptosomes / metabolism

Substances

  • Chlorides
  • Ion Channels
  • Receptors, GABA-A
  • Muscimol