NAD+ deficiency in age-related mitochondrial dysfunction

Tomas A Prolla; John M Denu

doi:10.1016/j.cmet.2014.01.005

NAD+ deficiency in age-related mitochondrial dysfunction

Cell Metab. 2014 Feb 4;19(2):178-80. doi: 10.1016/j.cmet.2014.01.005.

Authors

Tomas A Prolla¹, John M Denu²

Affiliations

¹ Departments of Genetics and Medical Genetics, University of Wisconsin, Madison, WI 53706, USA. Electronic address: taprolla@facstaff.wisc.edu.
² Department of Biomolecular Chemistry, University of Wisconsin, Madison, WI 53706, USA.

PMID: 24506863
DOI: 10.1016/j.cmet.2014.01.005

Abstract

Age-related mitochondrial dysfunction is thought to contribute to mammalian aging, particularly in postmitotic tissues that rely heavily on oxidative phosphorylation. A new study (Gomes et al., 2013) shows that reduced levels of nicotinamide adenine dinucleotide (NAD(+)) contribute to the mitochondrial decay associated with skeletal muscle aging and that sirtuin 1 (SIRT1) modulates this process.

Publication types

Comment

MeSH terms

Aging / pathology*
Animals
Cell Nucleus / metabolism*
Mitochondria / metabolism*
NAD / metabolism*
Oxidative Phosphorylation*

Substances

NAD

Abstract

Publication types

MeSH terms

Substances

Grants and funding