Role of infections

Kamen Rangelov; Sanjay Sethi

doi:10.1016/j.ccm.2013.09.012

Role of infections

Clin Chest Med. 2014 Mar;35(1):87-100. doi: 10.1016/j.ccm.2013.09.012.

Authors

Kamen Rangelov¹, Sanjay Sethi²

Affiliations

¹ Pulmonary and Critical Care Medicine, University at Buffalo, SUNY, 3435 Main Street, Buffalo, NY 14214, USA.
² Pulmonary, Critical Care, and Sleep Medicine, VA Western New York Healthcare System, University at Buffalo, The State University of New York, 3495 Bailey Avenue, Buffalo, NY 14215, USA. Electronic address: ssethi@buffalo.edu.

Abstract

This article represents a review of the current literature on the role of infection in the pathogenesis of chronic obstructive pulmonary disease (COPD), in stable disease, exacerbations, and pneumonia. It outlines the complex interactions between respiratory pathogens and host immune defenses that underlie the clinical manifestations of infection in COPD.

Keywords: Airway colonization; Chronic infection; Infection in COPD; Innate immunity in COPD; New strain exacerbations; Pneumonia and COPD; Vicious-circle hypothesis; Virulence factors.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Bacterial Infections / complications
Chronic Disease
Humans
Pulmonary Disease, Chronic Obstructive / complications*
Pulmonary Disease, Chronic Obstructive / physiopathology
Respiratory Tract Infections / complications*
Respiratory Tract Infections / physiopathology
Virus Diseases / complications