Abstract
The nucleolus is a multifunctional organelle with multiple roles involving cell proliferation, growth, survival, ribosome biogenesis and stress response signaling. Alteration of nucleolar morphology and architecture signifies an early response to increased cellular stress. This review briefly summarizes nucleolar response to cardiac stress signals and details the role played by nucleolar proteins in cardiovascular pathophysiology. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
Keywords:
Cardiovascular; Disease; Heart; Nucleolus.
© 2013.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Cardiovascular Diseases / genetics*
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Cardiovascular Diseases / metabolism
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Cardiovascular Diseases / physiopathology
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Cell Nucleolus / genetics
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Cell Nucleolus / metabolism*
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Cell Proliferation
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Fibrillins
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Humans
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Microfilament Proteins / metabolism
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Nuclear Proteins / metabolism*
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Nucleolin
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Nucleophosmin
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Phosphoproteins / metabolism*
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RNA-Binding Proteins / metabolism*
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Signal Transduction
Substances
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Fibrillins
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Microfilament Proteins
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Nuclear Proteins
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Phosphoproteins
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RNA-Binding Proteins
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Nucleophosmin