3D bioprinting of vascularized, heterogeneous cell-laden tissue constructs

Abstract

A new bioprinting method is reported for fabricating 3D tissue constructs replete with vasculature, multiple types of cells, and extracellular matrix. These intricate, heterogeneous structures are created by precisely co-printing multiple materials, known as bioinks, in three dimensions. These 3D micro-engineered environments open new -avenues for drug screening and fundamental studies of wound healing, angiogenesis, and stem-cell niches.

Keywords: 3D printing; biomaterials; bioprinting; tissue engineering; vasculature.