Asymmetric hydrogenation of disubstituted furans

Angew Chem Int Ed Engl. 2014 Aug 11;53(33):8751-5. doi: 10.1002/anie.201310985. Epub 2014 Feb 19.

Abstract

An enantioselective hydrogenation of disubstituted furans has been developed by using a chiral ruthenium catalyst with N-heterocyclic carbene ligands. This reaction converts furans into valuable enantioenriched disubstituted tetrahydrofurans.

Keywords: asymmetric catalysis; furans; heterocycles; homogeneous catalysis; hydrogenation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Catalysis
  • Furans / chemistry*
  • Heterocyclic Compounds / chemistry
  • Hydrogenation
  • Methane / analogs & derivatives
  • Methane / chemistry
  • Pressure
  • Ruthenium / chemistry
  • Solvents / chemistry
  • Stereoisomerism
  • Temperature

Substances

  • Furans
  • Heterocyclic Compounds
  • Solvents
  • carbene
  • Ruthenium
  • Methane