Medicine. Combating evolution to fight disease

Science. 2014 Mar 7;343(6175):1088-9. doi: 10.1126/science.1247472.

Abstract

Molecular mechanisms that generate biological diversity are rewriting ideas about how evolution proceeds, with implications for treating disease.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Antineoplastic Agents / pharmacology
  • Antineoplastic Agents / therapeutic use*
  • Biodiversity
  • DNA Replication / drug effects
  • Evolution, Molecular*
  • HSP90 Heat-Shock Proteins / metabolism
  • Humans
  • Mutagenesis
  • Neoplasm Invasiveness
  • Neoplasm Metastasis / drug therapy
  • Neoplasms / blood supply
  • Neoplasms / drug therapy*
  • Neoplasms / genetics*
  • Neovascularization, Pathologic / drug therapy
  • Protein Conformation

Substances

  • Antineoplastic Agents
  • HSP90 Heat-Shock Proteins