Extinction of a cocaine-taking context that protects against drug-primed reinstatement is dependent on the metabotropic glutamate 5 receptor

Addict Biol. 2015 May;20(3):482-9. doi: 10.1111/adb.12142. Epub 2014 Apr 9.

Abstract

We investigated the effects of extinguishing action-reward versus context-reward associations on drug-primed reinstatement, and the potential role of the metabotropic glutamate 5 receptor (mGlu5) in these different types of extinction in rats that self-administer cocaine. We observed that daily context extinction (non-reinforced exposures to the cocaine-taking context with retracted levers) was just as effective as daily lever extinction in reducing cocaine-primed reinstatement compared with passive abstinence. Additionally, systemic injections of the mGlu5 negative allosteric modulator MTEP (3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]-pyridine) following each extinction session significantly impaired the ability of context extinction to reduce cocaine-primed reinstatement, without affecting reinstatement after lever extinction or passive abstinence.

Keywords: Abstinence; MTEP; addiction; context; extinction; mGlu5.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Cocaine / pharmacology*
  • Conditioning, Operant
  • Dopamine Uptake Inhibitors / pharmacology*
  • Drug-Seeking Behavior / drug effects
  • Extinction, Psychological / drug effects
  • Male
  • Pyridines / pharmacology
  • Receptor, Metabotropic Glutamate 5 / antagonists & inhibitors
  • Receptor, Metabotropic Glutamate 5 / physiology*
  • Recurrence
  • Reward
  • Self Administration
  • Thiazoles / pharmacology

Substances

  • 3-((2-methyl-1,3-thiazol-4-yl)ethynyl)pyridine
  • Dopamine Uptake Inhibitors
  • Pyridines
  • Receptor, Metabotropic Glutamate 5
  • Thiazoles
  • Cocaine