Abstract
Effective interaction between T cells and their targets requires that recognition of specific antigen be coordinated with increased cell-cell adhesion. We show that antigen-receptor cross-linking increases the strength of the adhesion mechanism between lymphocyte function-associated molecule-1 (LFA-1) and intercellular adhesion molecules (ICAMs), with intracellular signals transmitted from the T-cell antigen receptor to the LFA-1 adhesion molecule. The increase in avidity is rapid and transient, providing a dynamic mechanism for antigen-specific regulation of lymphocyte adhesion and de-adhesion.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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1-Methyl-3-isobutylxanthine / pharmacology
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Alkaloids / pharmacology
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Antigens, Differentiation / physiology*
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Bucladesine / pharmacology
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Cell Adhesion Molecules / physiology*
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Cell Adhesion*
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Colforsin / pharmacology
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Humans
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In Vitro Techniques
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Lymphocyte Activation
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Lymphocyte Function-Associated Antigen-1
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Micelles
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Phorbol Esters / pharmacology
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Receptors, Antigen, T-Cell / physiology*
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Receptors, Leukocyte-Adhesion / physiology*
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Staurosporine
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T-Lymphocytes / physiology*
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Temperature
Substances
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Alkaloids
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Antigens, Differentiation
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Cell Adhesion Molecules
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Lymphocyte Function-Associated Antigen-1
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Micelles
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Phorbol Esters
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Receptors, Antigen, T-Cell
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Receptors, Leukocyte-Adhesion
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Colforsin
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Bucladesine
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Staurosporine
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1-Methyl-3-isobutylxanthine