Multiple sclerosis patients have a high frequency of an HLA-DQ beta epitope defined by a human-human hybridoma antibody

Tissue Antigens. 1989 May;33(5):546-9. doi: 10.1111/j.1399-0039.1989.tb01706.x.

Abstract

Epstein-Barr virus (EBV) transformed B-cells from patients with multiple sclerosis (MS) and healthy controls were analysed for reactivity with the HLA-DQ-specific human-human hybridoma Ab TrB12 (anti-DQw6 + DQw8 + DQw9) by indirect immunofluorescence (IIF). Positive results were obtained with 34 out of 35 MS patients (97.1%) and 79 out of 106 controls (74.5%) (p less than 0.005, RR = 11.6). Thus, DQ molecules that express the TrB12 epitope may contribute to the susceptibility to develop MS.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies / immunology*
  • Cell Line, Transformed
  • Epitopes / immunology*
  • HLA-DQ Antigens / immunology*
  • Herpesvirus 4, Human
  • Humans
  • Hybridomas / immunology*
  • Multiple Sclerosis / etiology
  • Multiple Sclerosis / immunology*
  • Oligonucleotides / immunology

Substances

  • Antibodies
  • Epitopes
  • HLA-DQ Antigens
  • Oligonucleotides