Abstract
The Drosophila segmentation gene, hairy (h), acts to regulate embryonic segmentation and bristle pattern. We present the DNA sequence of the h gene and of h cDNAs, thereby deducing the organization of the h transcripts. The h gene encodes a 337 amino acid protein that acts in both embryonic segmentation and adult bristle patterning. The h protein includes a domain that shows extensive similarity to a domain of the proto-oncogene N-myc that may be involved in DNA binding and/or protein dimerization. We discuss mechanisms of h action as a transcriptional regulator.
MeSH terms
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Amino Acid Sequence
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Animals
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Base Sequence
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Basic Helix-Loop-Helix Transcription Factors
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Blotting, Northern
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Cosmids
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DNA / genetics
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Drosophila / genetics*
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Drosophila Proteins*
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Genes*
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Insect Hormones
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Insect Proteins*
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Molecular Sequence Data
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Mutation
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Oncogenes*
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Phenotype
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RNA / genetics
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Repressor Proteins*
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Restriction Mapping
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Sequence Homology, Nucleic Acid
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Transcription Factors / analysis
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Transcription Factors / genetics*
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Transcription Factors / physiology
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Transcription, Genetic
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Transfection
Substances
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Basic Helix-Loop-Helix Transcription Factors
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Drosophila Proteins
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Insect Hormones
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Insect Proteins
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Repressor Proteins
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Transcription Factors
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hairy protein, Drosophila
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hairy protein, insect
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RNA
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DNA
Associated data
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GENBANK/X15904
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GENBANK/X15905