Abstract
RNase P, an enzyme that contains both RNA and protein components, cleaves tRNA precursors to generate mature 5' termini. The catalytic activity of RNase P resides in the RNA component, with the protein cofactor affecting the rate of the cleavage reaction. The reaction is also influenced by the nature of the tRNA substrate.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Catalysis
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Endoribonucleases / physiology*
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Nucleic Acid Conformation
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RNA / physiology*
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RNA Precursors / metabolism*
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RNA Splicing*
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RNA, Ribosomal, 23S / metabolism
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Ribonuclease P
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Substrate Specificity
Substances
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RNA Precursors
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RNA, Ribosomal, 23S
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RNA
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Endoribonucleases
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Ribonuclease P