Catalysis by the RNA subunit of RNase P--a minireview

Gene. 1989 Oct 15;82(1):63-4. doi: 10.1016/0378-1119(89)90030-9.

Abstract

RNase P, an enzyme that contains both RNA and protein components, cleaves tRNA precursors to generate mature 5' termini. The catalytic activity of RNase P resides in the RNA component, with the protein cofactor affecting the rate of the cleavage reaction. The reaction is also influenced by the nature of the tRNA substrate.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Catalysis
  • Endoribonucleases / physiology*
  • Nucleic Acid Conformation
  • RNA / physiology*
  • RNA Precursors / metabolism*
  • RNA Splicing*
  • RNA, Ribosomal, 23S / metabolism
  • Ribonuclease P
  • Substrate Specificity

Substances

  • RNA Precursors
  • RNA, Ribosomal, 23S
  • RNA
  • Endoribonucleases
  • Ribonuclease P