Launching Hsp70 neuroprotection: two drugs better than one

Cell Cycle. 2014;13(11):1657-8. doi: 10.4161/cc.29148. Epub 2014 May 8.

Authors

Pedro Fernandez-Funez¹, Diego E Rincon-Limas¹

Affiliation

¹ Departments of Neurology and Neuroscience; McKnight Brain Institute; Genetics Institute and Center for Translational Research on Neurodegenerative Diseases; University of Florida; Gainesville, FL USA.

No abstract available

Keywords: 17-DMGA; Drosophila; Geldanamycin; Hsp70; Hsp90; amyloid; dexamethasone; neurodegeneration; prion protein.

Publication types

Editorial

MeSH terms

Amyloid / genetics
Amyloid / metabolism*
DNA-Binding Proteins / metabolism
Gene Expression Regulation / genetics
Gene Expression Regulation / physiology*
HSP70 Heat-Shock Proteins / metabolism*
HSP90 Heat-Shock Proteins / metabolism
Heat Shock Transcription Factors
Humans
Models, Biological*
Molecular Chaperones / metabolism*
Neurodegenerative Diseases / prevention & control*
Proteostasis Deficiencies / prevention & control*
Transcription Factors / metabolism

Substances

Amyloid
DNA-Binding Proteins
HSP70 Heat-Shock Proteins
HSP90 Heat-Shock Proteins
Heat Shock Transcription Factors
Molecular Chaperones
Transcription Factors