Modulation of CD6 function through interaction with Galectin-1 and -3

FEBS Lett. 2014 Aug 25;588(17):2805-13. doi: 10.1016/j.febslet.2014.05.064. Epub 2014 Jun 16.

Abstract

CD6 is a lymphocyte glycoprotein receptor that physically associates with the antigen-specific receptor complex at the center of the immunological synapse, where it interacts with its ligand CD166/ALCAM. The present work reports the carbohydrate-dependent interaction of CD6 and CD166/ALCAM with Galectin-1 and -3, two well-known soluble mammalian lectins. Both galectins interfered with superantigen-induced T cell proliferation and cell adhesion phenomena mediated by the CD6-CD166/ALCAM pair, while CD6 expression protected cells from galectin-induced apoptosis. The results suggest that interaction of Galectin-1 and -3 with CD6 and CD166/ALCAM might modulate some relevant aspects of T cell physiology.

Keywords: ALCAM/CD166; Apoptosis; CD6; Cell adhesion; Galectin; T-cell activation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Activated-Leukocyte Cell Adhesion Molecule / metabolism*
  • Antigens, CD / metabolism*
  • Antigens, Differentiation, T-Lymphocyte / metabolism*
  • Apoptosis
  • B-Lymphocytes / cytology
  • Carbohydrate Metabolism
  • Cell Adhesion
  • Cell Membrane / metabolism
  • Dendritic Cells / immunology
  • Galectin 1 / metabolism*
  • Galectin 3 / metabolism*
  • Humans
  • Protein Binding
  • Superantigens / immunology
  • T-Lymphocytes / cytology
  • T-Lymphocytes / immunology

Substances

  • Activated-Leukocyte Cell Adhesion Molecule
  • Antigens, CD
  • Antigens, Differentiation, T-Lymphocyte
  • CD6 antigen
  • Galectin 1
  • Galectin 3
  • Superantigens