Roles of resolvins in the resolution of acute inflammation

Cell Biol Int. 2015 Jan;39(1):3-22. doi: 10.1002/cbin.10345. Epub 2014 Sep 17.

Abstract

Resolution is an active process that terminates inflammatory response to maintain health. Acute inflammation and its timely resolution are important in host response to danger signals. Unresolved inflammation is associated with widely recurrent diseases. Resolvins, including the D and E series, are endogenous lipid mediators generated during the resolution phase of acute of inflammation from the ω-3 PUFAs, DHA, and EPA. They have anti-inflammatory and pro-resolving properties that have been determined in many inflammation studies in animal models. In this review, we provide an updated overview of biosynthesis, actions, and signaling pathways of resolvins, thereby underscoring their diverse protective roles and introducing novel therapeutic strategies for inflammation-associated diseases.

Keywords: inflammation-associated diseases; polyunsaturated fatty acids; resolution; resolvin.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / metabolism
  • Anti-Inflammatory Agents / therapeutic use*
  • Docosahexaenoic Acids / metabolism
  • Docosahexaenoic Acids / therapeutic use*
  • Humans
  • Inflammation / drug therapy*
  • Inflammation Mediators / metabolism
  • MicroRNAs / metabolism
  • Mitogen-Activated Protein Kinases / metabolism
  • Phosphatidylinositol 3-Kinases / metabolism
  • Receptors, G-Protein-Coupled / metabolism

Substances

  • Anti-Inflammatory Agents
  • Inflammation Mediators
  • MicroRNAs
  • Receptors, G-Protein-Coupled
  • Docosahexaenoic Acids
  • Phosphatidylinositol 3-Kinases
  • Mitogen-Activated Protein Kinases