L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials

Org Biomol Chem. 2014 Sep 21;12(35):6816-9. doi: 10.1039/c4ob01362j.

Abstract

An l-rhamnose-based hydrogelator self-assembles to form nanofibrils, which, in contrast to the properties of monomeric l-rhamnose, suppress the antibody response of mice to phycoerythrin (PE), a fluorescent protein antigen. As the first example of the supramolecular assemblies of a saccharide to suppress immunity, this work illustrates a new approach of immunomodulation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adjuvants, Immunologic / chemistry
  • Animals
  • Antigen-Presenting Cells
  • Antigens / chemistry
  • DNA / chemistry
  • Enzyme-Linked Immunosorbent Assay
  • Epitopes / chemistry
  • Fluorescent Dyes / chemistry
  • Glycopeptides / chemistry
  • Humans
  • Hydrogels / chemistry
  • Hydrogen-Ion Concentration
  • Immune System
  • Immunoglobulin G / chemistry
  • Immunoglobulin M / chemistry
  • Immunosuppressive Agents / chemistry*
  • Liposomes / chemistry
  • Mice
  • Micelles
  • Microscopy, Electron, Transmission
  • Nanoparticles / chemistry*
  • Nanotechnology / methods
  • Peptides / chemistry
  • Rhamnose / chemistry*

Substances

  • Adjuvants, Immunologic
  • Antigens
  • Epitopes
  • Fluorescent Dyes
  • Glycopeptides
  • Hydrogels
  • Immunoglobulin G
  • Immunoglobulin M
  • Immunosuppressive Agents
  • Liposomes
  • Micelles
  • Peptides
  • DNA
  • Rhamnose