The growth-defense pivot: crisis management in plants mediated by LRR-RK surface receptors

Youssef Belkhadir; Li Yang; Jonathan Hetzel; Jeffery L Dangl; Joanne Chory

doi:10.1016/j.tibs.2014.06.006

The growth-defense pivot: crisis management in plants mediated by LRR-RK surface receptors

Trends Biochem Sci. 2014 Oct;39(10):447-56. doi: 10.1016/j.tibs.2014.06.006. Epub 2014 Aug 1.

Authors

Youssef Belkhadir¹, Li Yang², Jonathan Hetzel³, Jeffery L Dangl⁴, Joanne Chory⁵

Affiliations

¹ Gregor Mendel Institute, Austrian Academy of Sciences, Vienna Biocenter, Dr. Bohr-Gasse 3, 1030 Vienna, Austria.
² Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
³ Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA; Division of Biology, University of California, San Diego, Gilman Drive, La Jolla, CA 92037, USA.
⁴ Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Microbiology and Immunology, Coker Hall # 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Curriculum in Genetics, Coker Hall # 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Carolina Center for Genome Sciences, Coker Hall # 3280, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA. Electronic address: dangl@email.unc.edu.
⁵ Howard Hughes Medical Institute, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA; Plant Biology Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA. Electronic address: chory@salk.edu.

Abstract

Plants must adapt to their environment and require mechanisms for sensing their surroundings and responding appropriately. An expanded family of more than 200 leucine-rich repeat (LRR) receptor kinases (LRR-RKs) transduces fluctuating and often contradictory signals from the environment into changes in nuclear gene expression. Two LRR-RKs, BRASSINOSTEROID INSENSITIVE 1 (BRI1), a steroid receptor, and FLAGELLIN SENSITIVE 2 (FLS2), an innate immune receptor that recognizes bacterial flagellin, act cooperatively to partition necessary growth-defense trade-offs. BRI1 and FLS2 share common signaling components and slightly different activation mechanisms. BRI1 and FLS2 are paradigms for understanding the signaling mechanisms of LRR-containing receptors in plants.

Keywords: LRR-RKs; cell surface signaling; crosstalk; innate immunity; plant growth; trade-offs.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

MeSH terms

Arabidopsis / metabolism
Arabidopsis Proteins / genetics
Arabidopsis Proteins / metabolism*
Arabidopsis Proteins / physiology
Models, Molecular
Plant Development
Protein Kinases / genetics
Protein Kinases / physiology*
Protein Serine-Threonine Kinases / metabolism
Repetitive Sequences, Amino Acid
Signal Transduction / physiology*

Substances

Arabidopsis Proteins
Protein Kinases
FLS2 protein, Arabidopsis
BRI1 protein, Arabidopsis
Protein Serine-Threonine Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding