Polo-like kinase 4 shapes up

Michelle S Levine; Andrew J Holland

doi:10.1016/j.str.2014.07.004

Polo-like kinase 4 shapes up

Structure. 2014 Aug 5;22(8):1071-1073. doi: 10.1016/j.str.2014.07.004.

Authors

Michelle S Levine¹, Andrew J Holland²

Affiliations

¹ Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
² Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. Electronic address: aholland@jhmi.edu.

PMID: 25099950
DOI: 10.1016/j.str.2014.07.004

Abstract

Polo-like kinase 4 (Plk4) is a master regulator of centriole duplication and targets to centrioles through the association of its cryptic polo box domain with centriole receptors. In this issue of Structure, Shimanovskaya and colleagues unveil a new dimeric architecture of Plk4's cryptic polo box that reveals a conserved mechanism for centriole targeting of the kinase.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Caenorhabditis elegans / genetics*
Caenorhabditis elegans Proteins / chemistry*
Caenorhabditis elegans Proteins / metabolism*
Centrioles / physiology*
Models, Molecular*
Protein Kinases / chemistry*
Protein Kinases / metabolism*
Protein Serine-Threonine Kinases / metabolism*

Substances

Caenorhabditis elegans Proteins
Protein Kinases
zyg-1 protein, C elegans
Protein Serine-Threonine Kinases

Abstract

Publication types

MeSH terms

Substances

Grants and funding