Historical note: many steps led to the 'discovery' of thyroid-stimulating hormone

Eur Thyroid J. 2014 Jun;3(2):95-100. doi: 10.1159/000360534. Epub 2014 Mar 13.

Abstract

Finding thyroid-stimulating hormone was a process rather than a circumscribed event, and many talented persons participated over many years. Key early participants were Bennet M. Allen and Philip E. Smith who had the misfortune just prior to World War I of independently and simultaneously starting very similar experiments with tadpoles. This led to a series of back and forth publications attempting to establish priority for finding evidence of a thyrotropic factor in the anterior pituitary. Decades of work by others would be required before sophisticated biochemical techniques would bring us to our modern understanding.

Keywords: Discovery; History of science; Thyroid-stimulating hormone.

Publication types

  • Review