Abstract
Lymphomatoid granulomatosis (LyG) is a rare, B-cell derived, lymphoproliferative disorder that often presents as pulmonary nodular lesions with a histopathology of lymphatic invasion of the vascular wall. The development of LyG may be associated with reactivation of the Epstein-Barr virus under an immunosuppressive state. We herein report a case of Grade 3 LyG that developed during methotrexate therapy for rheumatoid arthritis and regressed following the withdrawal of the drug.
MeSH terms
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Aged
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Antirheumatic Agents / administration & dosage
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Antirheumatic Agents / adverse effects*
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Female
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Glucocorticoids / administration & dosage
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Humans
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Lung Neoplasms / chemically induced*
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Lung Neoplasms / diagnostic imaging
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Lung Neoplasms / drug therapy
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Lung Neoplasms / pathology
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Lymphomatoid Granulomatosis / chemically induced*
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Lymphomatoid Granulomatosis / diagnostic imaging
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Lymphomatoid Granulomatosis / drug therapy
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Lymphomatoid Granulomatosis / pathology
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Methotrexate / administration & dosage
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Methotrexate / adverse effects*
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Prednisolone / administration & dosage
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Radiography
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Sulfasalazine / administration & dosage
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Treatment Outcome
Substances
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Antirheumatic Agents
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Glucocorticoids
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Sulfasalazine
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Prednisolone
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Methotrexate