Genetic markers of cisplatin-induced hearing loss in children

B C Carleton; C J Ross; K Pussegoda; A P Bhavsar; H Visscher; J W Lee; B Brooks; S R Rassekh; M-P P Dubé; M R Hayden

doi:10.1038/clpt.2014.92

Genetic markers of cisplatin-induced hearing loss in children

Clin Pharmacol Ther. 2014 Sep;96(3):296-8. doi: 10.1038/clpt.2014.92.

Authors

B C Carleton¹, C J Ross², K Pussegoda³, A P Bhavsar⁴, H Visscher⁵, J W Lee⁴, B Brooks⁶, S R Rassekh⁷, M-P P Dubé⁸, M R Hayden⁹

Affiliations

¹ 1] Child and Family Research Institute, Vancouver, British Columbia, Canada [2] Division of Translational Therapeutics, Department of Pediatrics, The University of British Columbia, Vancouver, British Columbia, Canada [3] Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada.
² 1] Child and Family Research Institute, Vancouver, British Columbia, Canada [2] Division of Translational Therapeutics, Department of Pediatrics, The University of British Columbia, Vancouver, British Columbia, Canada [3] Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada [4] Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada.
³ Child and Family Research Institute, Vancouver, British Columbia, Canada.
⁴ 1] Child and Family Research Institute, Vancouver, British Columbia, Canada [2] Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada [3] Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada.
⁵ Department of Pediatrics, Amalia Children's Hospital, Radboud University Medical Centre, Nijmegen, The Netherlands.
⁶ Audiology and Speech Pathology Department, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
⁷ 1] Child and Family Research Institute, Vancouver, British Columbia, Canada [2] Pharmaceutical Outcomes Programme, BC Children's Hospital, Vancouver, British Columbia, Canada [3] Department of Pediatrics, Division of Pediatric Hematology/Oncology/Bone Marrow Transplant, British Columbia Children's Hospital, Vancouver, British Columbia, Canada.
⁸ Montreal Heart Institute Research Centre and Université de Montreal, Montreal, QC, Canada.
⁹ Centre for Molecular Medicine and Therapeutics, Department of Medical Genetics, The University of British Columbia, Vancouver, British Columbia, Canada.

PMID: 25141953
DOI: 10.1038/clpt.2014.92

Abstract

This journal recently published a Commentary by Ratain and colleagues at the University of Chicago that criticizes our work on cisplatin-induced hearing loss in children. It is unfortunate that neither the authors nor the editors of Clinical Pharmacology & Therapeutics corresponded with us to provide an earlier opportunity to address these questions. Here we correct the authors' inaccuracies and provide additional analyses that further strengthen our published findings.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Antineoplastic Agents / adverse effects*
Antineoplastic Agents / toxicity*
Catechol O-Methyltransferase / genetics*
Cisplatin / adverse effects*
Cisplatin / toxicity*
Female
Genetic Variation*
Hearing Loss / chemically induced*
Hearing Loss / genetics*
Humans
Male
Methyltransferases / genetics*
Multidrug Resistance-Associated Proteins / genetics*

Substances

Antineoplastic Agents
Multidrug Resistance-Associated Proteins
Methyltransferases
Catechol O-Methyltransferase
Cisplatin

Grants and funding

Canadian Institutes of Health Research/Canada