Safety Assessment of PEGylated oils as used in cosmetics

Christina L Burnett; Bart Heldreth; Wilma F Bergfeld; Donald V Belsito; Ronald A Hill; Curtis D Klaassen; Daniel C Liebler; James G Marks Jr; Ronald C Shank; Thomas J Slaga; Paul W Snyder; F Alan Andersen

doi:10.1177/1091581814546337

Safety Assessment of PEGylated oils as used in cosmetics

Int J Toxicol. 2014 Nov-Dec;33(4 Suppl):13S-39S. doi: 10.1177/1091581814546337. Epub 2014 Aug 27.

Affiliations

¹ Cosmetic Ingredient Review Scientific Analyst/Writer, Washington, DC, USA.
² Cosmetic Ingredient Review Chemist, Washington, DC, USA.
³ Cosmetic Ingredient Review Expert Panel Member, Washington, DC, USA.
⁴ Former Director, Cosmetic Ingredient Review, Washington, DC, USA.

PMID: 25163475
DOI: 10.1177/1091581814546337

Abstract

PEGylated oil is a terminology used to describe cosmetic ingredients that are the etherification and esterification products of glycerides and fatty acids with ethylene oxide. The Cosmetic Ingredient Review Expert Panel (Panel) considered the safety of PEGylated oils, which function primarily as surfactants in cosmetic products. The Panel reviewed relevant animal and human data provided in this safety assessment and concluded that the 130 chemically related PEGylated oils were safe as cosmetic ingredients in the present practices of use and concentration when formulated to be nonirritating.

Keywords: PEGylated oils; cosmetics; safety.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Castor Oil / analogs & derivatives*
Castor Oil / toxicity
Consumer Product Safety
Cosmetics / toxicity*
Dermatitis, Irritant / etiology*
Humans
Polyethylene Glycols / toxicity*
Risk Assessment
Surface-Active Agents / toxicity*
United States

Substances

Cosmetics
Surface-Active Agents
Polyethylene Glycols
polyethoxylated castor oil
Castor Oil