1 From the Partners Program in Computational Pathology and the Department of Pathology, Massachusetts General Hospital, Boston (Drs Louis, Baron, Dighe, Getz, Higgins, Michaelson, Le, Mermel, and Gilbertson); the Department of Pathology, Brigham and Women's Hospital, Boston (Drs Gerber, Bry, Kuo, Lane, and Golden); the Departments of Pathology (Drs Louis, Gerber, Baron, Bry, Dighe, Getz, Kuo, Lane, Michaelson, Le, Mermel, Gilbertson, and Golden) and Systems Biology (Dr Higgins), Harvard Medical School, Boston; and the Broad Institute, Cambridge, Massachusetts (Drs Getz, Le, and Mermel). Drs Louis, Gilbertson, and Golden are co-senior authors.