Hydrophobic triaryl-substituted β-lactams as activity-based probes for profiling eukaryotic enzymes and host-pathogen interactions

Chembiochem. 2014 Oct 13;15(15):2195-200. doi: 10.1002/cbic.201402097. Epub 2014 Sep 1.
No abstract available

Keywords: activity-based protein profiling; beta-lactams; eukaryote; hepatitis C virus; mass spectrometry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Line, Tumor
  • Enzymes / chemistry*
  • Enzymes / metabolism
  • Eukaryotic Cells / enzymology*
  • Eukaryotic Cells / metabolism
  • Eukaryotic Cells / microbiology
  • Host-Pathogen Interactions*
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Molecular Conformation
  • Molecular Probes / chemical synthesis
  • Molecular Probes / chemistry*
  • Molecular Probes / metabolism
  • beta-Lactams / chemical synthesis
  • beta-Lactams / chemistry*
  • beta-Lactams / metabolism

Substances

  • Enzymes
  • Molecular Probes
  • beta-Lactams