New pROSpects for PTP1B: micro-managing oncogene-induced senescence

Robert S Banh; Yang Xu; Benjamin G Neel

doi:10.1016/j.molcel.2014.08.015

New pROSpects for PTP1B: micro-managing oncogene-induced senescence

Mol Cell. 2014 Sep 4;55(5):651-3. doi: 10.1016/j.molcel.2014.08.015.

Authors

Robert S Banh¹, Yang Xu¹, Benjamin G Neel²

Affiliations

¹ Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada.
² Princess Margaret Cancer Centre, University Health Network, Toronto, ON M5G 1L7, Canada; Department of Medical Biophysics, University of Toronto, Toronto, ON M5G 2M9, Canada. Electronic address: bneel@uhnresearch.ca.

PMID: 25192363
DOI: 10.1016/j.molcel.2014.08.015

Abstract

Oncogene-induced senescence (OIS) provides an important, but incompletely understood, barrier to tumorigenesis. In this issue, Yang et al. (2014) surprisingly report that inactivation of PTP1B by reactive oxygen species is essential for OIS, via effects on AGO2 and microRNA maturation.

Publication types

Comment

MeSH terms

Argonaute Proteins / metabolism*
Gene Silencing*
Humans
Protein Tyrosine Phosphatase, Non-Receptor Type 1 / physiology*
Tyrosine / metabolism*
ras Proteins / physiology*

Substances

AGO2 protein, human
Argonaute Proteins
Tyrosine
Protein Tyrosine Phosphatase, Non-Receptor Type 1
ras Proteins