Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study

Alexandria M Reynolds; Denise M Peters; Jennifer M C Vendemia; Lenwood P Smith; Raymond C Sweet; Gordon C Baylis; Debra Krotish; Stacy L Fritz

doi:10.4103/1673-5374.131589

Neuronal injury in the motor cortex after chronic stroke and lower limb motor impairment: a voxel-based lesion symptom mapping study

Neural Regen Res. 2014 Apr 1;9(7):766-72. doi: 10.4103/1673-5374.131589.

Authors

Alexandria M Reynolds¹, Denise M Peters², Jennifer M C Vendemia³, Lenwood P Smith⁴, Raymond C Sweet⁴, Gordon C Baylis⁵, Debra Krotish⁶, Stacy L Fritz²

Affiliations

¹ Department of Psychology, Barnwell College, University of South Carolina, Columbia, SC, USA.
² Department of Exercise Science, University of South Carolina, Columbia, SC, USA.
³ Department of Psychology, University of South Carolina, Columbia, SC, USA.
⁴ Neurosurgery Center, University of South Carolina School of Medicine, Columbia, SC, USA.
⁵ Western Kentucky University, Bowling Green, KY, USA.
⁶ University of South Carolina School of Medicine, Columbia, SC, USA.

Abstract

Many studies have examined motor impairments using voxel-based lesion symptom mapping, but few are reported regarding the corresponding relationship between cerebral cortex injury and lower limb motor impairment analyzed using this technique. This study correlated neuronal injury in the cerebral cortex of 16 patients with chronic stroke based on a voxel-based lesion symptom mapping analysis. Neuronal injury in the corona radiata, caudate nucleus and putamen of patients with chronic stroke could predict walking speed. The behavioral measure scores were consistent with motor deficits expected after damage to the cortical motor system due to stroke. These findings suggest that voxel-based lesion symptom mapping may provide a more accurate prognosis of motor recovery from chronic stroke according to neuronal injury in cerebral motor cortex.

Keywords: cerebral cortex; magnetic resonance imaging; motor cortex; motor function; nerve regeneration; neural regeneration; prognosis; stroke; voxel-based lesion symptom mapping.