Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa

Lancet Neurol. 2014 Oct;13(10):1029-44. doi: 10.1016/S1474-4422(14)70114-0.

Abstract

Epilepsy is a common neurological disease in tropical countries, particularly in sub-Saharan Africa. Previous work on epilepsy in sub-Saharan Africa has shown that many cases are severe, partly a result of some specific causes, that it carries a stigma, and that it is not adequately treated in many cases. Many studies on the epidemiology, aetiology, and management of epilepsy in sub-Saharan Africa have been reported in the past 10 years. The prevalence estimated from door-to-door studies is almost double that in Asia, Europe, and North America. The most commonly implicated risk factors are birth trauma, CNS infections, and traumatic brain injury. About 60% of patients with epilepsy receive no antiepileptic treatment, largely for economic and social reasons. Further epidemiological studies should be a priority to improve understanding of possible risk factors and thereby the prevention of epilepsy in Africa, and action should be taken to improve access to treatment.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Africa South of the Sahara / epidemiology
  • Age Distribution
  • Anticonvulsants / therapeutic use
  • Birth Injuries / complications
  • Brain Injuries / complications
  • Central Nervous System Infections / complications
  • Central Nervous System Infections / epidemiology
  • Drug Utilization
  • Epilepsy* / epidemiology
  • Epilepsy* / etiology
  • Epilepsy* / genetics
  • Epilepsy* / therapy
  • Humans
  • Incidence
  • Malnutrition / complications
  • Prevalence
  • Risk Factors
  • Seizures / physiopathology
  • Seizures, Febrile / epidemiology
  • Sex Distribution
  • Socioeconomic Factors

Substances

  • Anticonvulsants