Abstract
The aim of this paper is to know the iron dynamics and action of the collagen-Fe2+ complex at tissular level. The results showed that the collagen-Fe2+ complex is biocompatible at tissular level and the ferrous iron entered the animal organism on the well-known metabolic pathways. When a high dose of the complex was administered, an overloading with hemosiderin of macrophages and hepatocytes was noticed.
MeSH terms
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Animals
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Collagen / pharmacokinetics
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Collagen / pharmacology*
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Dose-Response Relationship, Drug
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Drug Combinations
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Ferrous Compounds / pharmacokinetics
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Ferrous Compounds / pharmacology*
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Hemosiderin / metabolism
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Male
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Metalloproteins / pharmacokinetics
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Metalloproteins / pharmacology*
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Rats
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Tissue Distribution
Substances
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Drug Combinations
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Ferrous Compounds
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Metalloproteins
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collagen-ferrous complex
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ferrous sulfate
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Collagen
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Hemosiderin