A universal molecular translator for non-nucleic acid targets that enables dynamic DNA assemblies and logic operations

Wei Tang; Shichao Hu; Huaming Wang; Yan Zhao; Na Li; Feng Liu

doi:10.1039/c4cc07041k

A universal molecular translator for non-nucleic acid targets that enables dynamic DNA assemblies and logic operations

Chem Commun (Camb). 2014 Nov 28;50(92):14352-5. doi: 10.1039/c4cc07041k.

Authors

Wei Tang¹, Shichao Hu, Huaming Wang, Yan Zhao, Na Li, Feng Liu

Affiliation

¹ Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China. liufeng@pku.edu.cn.

PMID: 25295484
DOI: 10.1039/c4cc07041k

Abstract

A universal molecular translator based on the target-triggered DNA strand displacement was developed, which was able to convert various kinds of non-nucleic acid targets into a unique output DNA. This translation strategy was successfully applied in directing dynamic DNA assemblies and in realizing three-input logic gate operations.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adenosine Triphosphate / chemistry
Aptamers, Nucleotide / chemistry
DNA / chemistry*
Hydrogen / chemistry
Logic
Strontium / chemistry
Thrombin / chemistry

Substances

Aptamers, Nucleotide
Hydrogen
Adenosine Triphosphate
DNA
Thrombin
Strontium