Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors

Christian Berrios; Joonil Jung; Blake Primi; Michael Wang; Chandrasekhar Pedamallu; Fujiko Duke; Christina Marcelus; Jingwei Cheng; Robert L Garcea; Matthew Meyerson; James A DeCaprio

doi:10.1128/JVI.02328-14

Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors

J Virol. 2015 Jan;89(1):857-62. doi: 10.1128/JVI.02328-14. Epub 2014 Oct 15.

Authors

Affiliations

¹ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Program in Virology, Harvard University Graduate School of Arts and Sciences, Division of Medical Sciences, Boston, Massachusetts, USA.
² Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
³ Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, Colorado, USA The BioFrontiers Institute, University of Colorado, Boulder, Colorado, USA.
⁴ Department of Pediatrics, University of Colorado School of Medicine, Denver, Colorado, USA.
⁵ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA.
⁶ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA.
⁷ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA.
⁸ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.
⁹ Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA Program in Virology, Harvard University Graduate School of Arts and Sciences, Division of Medical Sciences, Boston, Massachusetts, USA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA james_decaprio@dfci.harvard.edu.

Abstract

Malawi polyomavirus (MWPyV) is a recently identified human polyomavirus. Serology for MWPyV VP1 indicates that infection frequently occurs in childhood and reaches a prevalence of 75% in adults. The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53. However, the MWPyV LT was less stable than the simian virus 40 (SV40) LT and was unable to promote the growth of normal cells. This report confirms that MWPyV is a widespread human virus expressing T antigens with low transforming potential.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

MeSH terms

Adolescent
Adult
Aged
Aged, 80 and over
Antigens, Viral, Tumor / metabolism*
Child
Child, Preschool
DNA, Viral / chemistry
DNA, Viral / genetics
Female
Host-Pathogen Interactions*
Humans
Infant
Male
Middle Aged
Molecular Sequence Data
Polyomavirus / physiology*
Polyomavirus Infections / epidemiology*
Polyomavirus Infections / virology
Protein Binding
Sequence Analysis, DNA
Seroepidemiologic Studies
Tumor Suppressor Proteins / metabolism*
Young Adult

Malawi polyomavirus is a prevalent human virus that interacts with known tumor suppressors

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Abstract

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