Abstract
Therapeutic options for gastric variceal bleeding in the presence of extensive portal vein thrombosis associated with a myeloproliferative disorder are limited. We report a case of a young woman who presented with gastric variceal bleeding secondary to extensive splanchnic venous thrombosis due to a Janus kinase 2 mutation associated myeloproliferative disorder that was managed effectively with partial splenic embolization.
Keywords:
Gastric varices; Janus kinase 2, Portal hypertension; Myeloproliferative disorder; Partial splenic embolization; Portal vein thrombosis.
MeSH terms
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Adult
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Embolization, Therapeutic / methods*
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Esophageal and Gastric Varices / diagnosis
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Esophageal and Gastric Varices / etiology
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Esophageal and Gastric Varices / therapy*
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Female
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Gastrointestinal Hemorrhage / diagnosis
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Gastrointestinal Hemorrhage / etiology
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Gastrointestinal Hemorrhage / therapy*
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Humans
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Janus Kinase 2 / genetics
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Magnetic Resonance Imaging
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Mutation
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Myeloproliferative Disorders / complications*
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Myeloproliferative Disorders / diagnosis
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Myeloproliferative Disorders / enzymology
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Myeloproliferative Disorders / genetics
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Myeloproliferative Disorders / therapy
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Portal Vein*
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Splenic Artery*
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Treatment Outcome
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Venous Thrombosis / diagnosis
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Venous Thrombosis / drug therapy
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Venous Thrombosis / etiology*
Substances
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JAK2 protein, human
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Janus Kinase 2