Treatment of gastric varices with partial splenic embolization in a patient with portal vein thrombosis and a myeloproliferative disorder

World J Gastroenterol. 2014 Oct 21;20(39):14495-9. doi: 10.3748/wjg.v20.i39.14495.

Abstract

Therapeutic options for gastric variceal bleeding in the presence of extensive portal vein thrombosis associated with a myeloproliferative disorder are limited. We report a case of a young woman who presented with gastric variceal bleeding secondary to extensive splanchnic venous thrombosis due to a Janus kinase 2 mutation associated myeloproliferative disorder that was managed effectively with partial splenic embolization.

Keywords: Gastric varices; Janus kinase 2, Portal hypertension; Myeloproliferative disorder; Partial splenic embolization; Portal vein thrombosis.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Embolization, Therapeutic / methods*
  • Esophageal and Gastric Varices / diagnosis
  • Esophageal and Gastric Varices / etiology
  • Esophageal and Gastric Varices / therapy*
  • Female
  • Gastrointestinal Hemorrhage / diagnosis
  • Gastrointestinal Hemorrhage / etiology
  • Gastrointestinal Hemorrhage / therapy*
  • Humans
  • Janus Kinase 2 / genetics
  • Magnetic Resonance Imaging
  • Mutation
  • Myeloproliferative Disorders / complications*
  • Myeloproliferative Disorders / diagnosis
  • Myeloproliferative Disorders / enzymology
  • Myeloproliferative Disorders / genetics
  • Myeloproliferative Disorders / therapy
  • Portal Vein*
  • Splenic Artery*
  • Treatment Outcome
  • Venous Thrombosis / diagnosis
  • Venous Thrombosis / drug therapy
  • Venous Thrombosis / etiology*

Substances

  • JAK2 protein, human
  • Janus Kinase 2