Aciclovir-induced neurotoxicity: Utility of CSF and serum CMMG levels in diagnosis

L Berry; P Venkatesan

doi:10.1016/j.jcv.2014.09.001

Aciclovir-induced neurotoxicity: Utility of CSF and serum CMMG levels in diagnosis

J Clin Virol. 2014 Dec;61(4):608-10. doi: 10.1016/j.jcv.2014.09.001. Epub 2014 Sep 17.

Authors

L Berry¹, P Venkatesan²

Affiliations

¹ Department of Infectious Diseases, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, United Kingdom(1). Electronic address: Louise.berry@nuh.nhs.uk.
² Department of Infectious Diseases, Nottingham City Hospital, Hucknall Road, Nottingham NG5 1PB, United Kingdom(1).

PMID: 25440915
DOI: 10.1016/j.jcv.2014.09.001

Abstract

Aciclovir is an anti-viral frequently used for herpes virus infections. Neurotoxicity and nephrotoxicity are uncommon but serious side effects of aciclovir treatment. This case illustrates how aciclovir induced neurotoxicity can present and how it can be diagnosed using quantitative assays of aciclovir and its metabolite in the CSF and serum.

Keywords: 9-Carboxymethoxymethylguanine; ACV; Aciclovir; CMMG; Neurotoxicity.

Publication types

Case Reports

MeSH terms

Acyclovir / adverse effects*
Acyclovir / therapeutic use
Aged
Antiviral Agents / adverse effects*
Antiviral Agents / therapeutic use
Cerebrospinal Fluid / chemistry
Female
Guanine / analogs & derivatives*
Guanine / blood
Guanine / cerebrospinal fluid
Humans
Neurotoxicity Syndromes / diagnosis*
Serum / chemistry

Substances

Antiviral Agents
Guanine
9-carboxymethoxymethylguanine
Acyclovir